Publications

Selected International peer-reviewed publications in Breast cancer:

1- Sabet, S.F., El-Sayed, S.K., Mohamed H.T., El-Shinawi, M. Mohamed, M.M.  Inflammatory breast cancer: High incidence of GCC haplotypes (-1082 A/G, -819 T/C, -592 A/C) in the IL-10 gene promoter correlates with over-expression of IL-10 in the carcinoma tissues. (2017),Tumor Biol.

2- Ibrahim, S.A.,Gadalla, R., El-Ghonaimy, A.A., Samir, O., Mohamed, H.T., Hassan, H., Greve, B., El-Shinawi,M., Mohamed, M.M., Götte, M.   Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3 and Notch/EGFR axis signaling pathways. (2017) Mol Cancer, 16(1):57. PMID:28270211

3- Hosny, M., Sabet,S., El-Shinawi, M., Gaafar, K.M., Mohamed, M.M.   Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer. (2017) Experimental and Therapeutic Medicine (Esub 173063). https://www.spandidos-publications.com/etm/13/5/2235

4- Elghonaimy EA, Ibrahim SA, Youns A, Hussein Z, Nouh MA, El-Mamlouk T, El-Shinawi M, Mostafa Mohamed M. (2016) Secretome of tumor-associated leukocytes augment epithelial-mesenchymal transition in positive lymph node breast cancer patients via activation of EGFR/Tyr845 and NF-κB/p65 signaling pathway. Tumour Biol. 2016 Jun 22 DOI: 10.1007/s13277-016-5123-x PMID: 27329104.

5- Sherif A. Ibrahim, Eslam A. El-Ghonaimy, Hebatallah Hassan, Noha MahanaMahmoud Abdelbaky Mahmoud, Tahani El-Mamlouk, Mohamed El-Shinawi, Mona M. Mohamed. Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression. JAR (2016) doi:10.1016/j.jare.2016.06.007.

6- El-Shinawi M, Mohamed KO, Fouad YA, Fahmy YM, Asar HA, Khalil MG, Anestidou L, El-Kamary SS, Mohamed MM. Assessing the Awareness of Egyptian Medical Students about Responsible Conduct of Research and Research Ethics: Impact of an Educational Campaign. Account Res. 2016;23 (4):199-218. doi: 10.1080/08989621.2015.1127762. PMID: 26647065

7- El-Shinawi M, Mohamed HT, Abdel-Fattah HH, Ibrahim SA, El-Halawany MS, Nouh MA, Schneider RJ, Mohamed MM.  Inflammatory and Non-inflammatory Breast Cancer: A Potential Role for Detection of Multiple Viral DNAs in Disease Progression. Ann Surg Oncol. 2016 Feb;23(2):494-502. doi: 10.1245/s10434-015-4888-2. PMID: 26508152

8- El-Ghonaimy, E., El-Shinawi, M., Ibrahim, S., El-Ghazaly, H., Abd-El-Tawab, R., Nouh, M, El-Mamlouk, T, Mohamed, M.M. (2014) Positive lymph-node breast cancer patients: Activation of NF-κB in tumor associated leukocytes stimulates cytokines secretion that promotes metastasis via CC-chemokine receptor CCR7. FEBS J. 2014 Oct 18. doi: 10.1111/febs.13124. PMID:25327843

9- Mohamed, H.T., El-Shinawi, M., Nouh, M.A., Elsayed, T.E., Bashtar, A., Schneider, R.J., Mohamed, M.M. (2014) Inflammatory breast cancer: high incidence of detection of mixed human cytomegalovirus genotypes associated with disease pathogenesis. Front. Oncol., 11 September 2014 | doi: 10.3389/fonc.2014.00246. PMID:25309872

10- Mohamed, M.M., Sabet, S.F., Peng, D., Nouh, A.M., El-Shinawi, M., El-Rifai, W. (2014) Promoter hypermethylation and suppression of glutathione peroxidase-3 is associated with inflammatory breast carcinogenesis. Oxid Med Cell Longev., 787195. PMID: 24790704

11- Mohamed, M.M., El-Ghonaimy, E.A., Nouh, M.A., Schneider, R.J., Sloane, B.F., El-Shinawi, M. (2014). Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties. The Int J Biochem Cell Biol., 46:138-47. PMID: 24291763

12- El-Shinawi, M.,Youssef, A., Alsara, M., Aly, M.K., Mostafa, M., Yehia, M., Hurlbert, M., Abd El-Tawab, R., Mohamed M.M. (2013).Assessing the level of breast cancer awareness among recently diagnosed patients in Ain Shams University hospital. The Breast., 22(6):1210-1214. PMID: 24054904

13- Mohamed, M.M., Al-Raawi, D., Sabet, S.F., El-Shinawi, M. (2013). Inflammatory breast cancer: new factors contribute to disease etiology. Journal of Advanced Research. PMID: 25685520

14- El-Shinawi, M., Mohamed, H.T., El-Ghonaimy, E.A., Tantawy, M., Younis, A., Schneider, R.J., Mohamed, M.M. (2013) Human Cytomegalovirus Infection Enhances NF-kappaB/p65 Signaling in Inflammatory Breast Cancer Patients. PLoS One, 8(2):e55755. PMID: 23418456

15- Mohamed, M.M. (2012). Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway. Cell Commun Signal, 10(1): 3. PMID: 22321604

16- Al-Raawi, D., Abu-El-Zahab, H., El-Shinawi, M., Mohamed, M.M. (2011). Membrane   type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer. Int J Clin Exp Med, 4, 265-275. PMID: 22140598

17- Victor, B.C., Anbalagan, A., Mohamed, M.M., Sloane, B.F., Cavallo-Medved, D. (2011). Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion. Breast Cancer Res 13, R115. PMID: 22093547

18- Nouh, M. A., Mohamed, M. M., El-Shinawi, M., Shaalan, M. A., Cavallo-Medved, D., Khaled, H. M., and Sloane, B. F. (2011) Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med 9, 1. PMID: 21199580

19- El-Shinawi, M., Abdelwahab, S. F., Sobhy, M., Nouh, M. A., Sloane, B. F., and Mohamed, M. M. (2010) Capturing and characterizing immune cells from breast tumor microenvironment: an innovative surgical approach. Ann Surg Oncol 17, 2677-2684. PMID: 20333554

20- Mohamed, M. M., Cavallo-Medved, D., Rudy, D., Anbalagan, A., Moin, K., and Sloane, B. F. (2010) Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes. PMID: 20110692

21- Mohamed, M. M., Cavallo-Medved, D., and Sloane, B. F. (2008) Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer. Biol Chem 389, 1117-1121. PMID: 18710343

22- Mohamed, M. M., and Sloane, B. F. (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6, 764-775. PMID: 16990854

23- Ibrahim SA, Hassan H, Götte M. microRNA regulation of proteoglycan function in cancer. FEBS J. 2014 Aug 28. doi: 10.1111/febs.13026. PMID: 25168226

24- Kumar AV, Gassar ES, Spillmann D, Stock C, Sen JP, Zhang T, van Kuppevelt TH, Hülsewig C, Eliene Koszl wski 6, Pavao MS, Ibrahim SA, Poeter M, Rescher M, Kiesel L, Koduru S, Yip GY, Götte M .HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression. Int J Cancer. 2014 Apr 20.PMID: 24752740

25- Ibrahim SA, Hassan H, Götte M. MicroRNA-dependent targeting of the extracellular matrix as a mechanism of regulating cell behavior. Biochim Biophys Acta. 2014 Jan 23. pii: S0304-4165(14)00032-4.PMID: 24462576

26- Ibrahim SA, Hassan H, Vilardo L, Kumar SK, Kumar AV, Kelsch R, Schneider C, Kiesel L, Eich HT, Zucchi I, Reinbold R, Greve B, Götte M. Syndecan-1 (CD138) modulates breast cancer stem cell properties via regulation of IL-6- mediated STAT3 signaling. PLoS One. 2013 Dec 31;8(12):e85737.PMID: 24392029

27- Hassan H, Greve B, Pavao MS, Kiesel L, Ibrahim SA, Götte M. Syndecan-1 modulates beta-integrin- and IL-6-dependent functions in breast cancer cell adhesion, migration and resistance to irradiation. FEBS J. 2013 May;280(10):2216-27.PMID: 23289672

28- Ibrahim SA, Yip GW, Stock C, Pan JW, Neubauer C, Poeter M, Pupjalis D, Koo CY, Kelsch R, Schüle R, Rescher U, Kiesel L, Götte M. Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. Int J Cancer. 2012 Sep 15; 131(6):E884-96.PMID: 22573479

29- Ezeddin Salem Gassar, Sherif A. Ibrahim, Götte Martin. Heparan sulfate proteoglycans in cancer progression and therapy. in ” Glycans in Diseases and Therapeutics”. Series, Biology of Extracellular Matrix, Editor: Pavão M. Springer Berlin Heidelberg     publisher, 2011, pp 139-158.

29- Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW. miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. Oncogene. 2010 Dec 16;29(50):6569-80.PMID: 20818426

30- Nikolova   V, Koo CY, Ibrahim SA, Wang Z, Spillmann D, Dreier R, Kelsch R, Fischgräbe J, Smollich M, Rossi LH, Sibrowski W, Wülfing P, Kiesel L, Yip GW, Götte M. Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis. 2009 Mar;30(3):397-407.PMID: 19126645

31- Ibrahim SA, Abdelwahab SF, Mohamed MM, Osman AM, Fathy E, Al-Badry KS, Al-Kady N, Esmat GE, Al-Sherbiny MM. T cells are depleted in HCV-Induced hepatocellular carcinoma patients: possible role of apoptosis and p53. Egypt J Immunol. 2006;13(2):11-22.PMID: 18689267

32- Schneider C1, Kässens N, Greve B, Hassan H, Schüring AN, Starzinski-Powitz A, Kiesel L, Seidler DG, Götte M. Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion. Fertil Steril. 2013 Mar 1;99(3):871-881. PMID: 23206733

33-    Ibrahim SA, Gadalla R, El-Ghonaimy EA, Samir OMohamed HTHassan HGreve BEl-Shinawi MMohamed MMGötte M. Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways. Molecular Cancer. 2017;16:57. PMID:28270211

34-  Sabet S, El-Sayed SK, Mohamed HT, El-Shinawi M, Mohamed MM. Inflammatory breast cancer: High incidence of GCC haplotypes (-1082A/G, -819T/C, and -592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues.Tumour Biol. 2017 Jul;39(7). PMID: 28675120

Selected International peer-reviewed Posters and Abstracs in Breast cancer :

1- Sherif A. Ibrahim, Eslam A. El-Ghonaimy, Mohamed El-Shinawi, Medhat S. El-Halawany, M. Akram Nouh, Tahani El-Mamlouk, Bonnie F. Sloane, Mona Mostafa Mohamed . “MCP-1/CCL2 and IL-8 regulate proteolytic activity of triple negative inflammatory breast cancer via cathepsin B, ERK1/2, JAK1 and Src signaling pathway “AACR annual meeting April 18 – 22, 2015, Pennsylvania Convention Center Philadelphia, Pennsylvania

2- Hossam taha Mohamed, Hadeer Hesham Abdel Fattah, Mohamed El-Shinawi, Sherif Abdelaziz Ibrahim, Medhat S. El-Halawany, Hesham El Ghazaly, Robert Schneider, Mona Mohamed “Inflammatory breast cancer: Mixed viral infections within carcinoma tissues and the expression of Ki-67 proliferation marker” ASCO Annual Meeting (May 29 – June 2, 2015) McCormic place, Chicago, Illinois.

3- Mohamed, M.M., El-Ghonaimy, E.A., Nouh, M.A., Schneider, R.J., Sloane, B.F.,   El-Shinawi, M. (2013) Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties Third AACR International Conference on Frontiers in Basic Cancer Research, September 18-22, 2013 National Harber, Maryland, USA.

4- Mohamed, H.T., El-Shinawi, M., El-Ghonaimy, E.A. Bashtar, A., Abdel-salam, T.S. Schneider, R.F., Mohamed, M.M. (2013) Detection of different genotypes of Human Cytomegalovirus in breast cancer patients, AACR Annual Meeting, April 6-10, 2013, Washington, DC, USA.

5- El-Ghonaimy, E.A., El-Shinawi, M., El-Mamlouk, T., Abd-El-Tawab, R., Sloane, B.F., Mohamed, M.M. (2012). Biological characterization of tumor-associated leukocytes in positive and negative lymph node breast cancer patients CTRC-AACR San Antonio Breast Cancer Symposium.

6- Mohamed, M. M. (2011) Macrophage Infiltration and Cathepsin B Expression in the Tumor Microenvironment of Inflammatory Breast Cancer Patients Correlates with Lymph Node Metastasis. Oral presentation presented by Mr. Ayman Maher at The 5th Middle East Best of CTRC-AARC San Antonio Breast Cancer Symposium, Riyadh, Saudi Arabia, (Awarded prize of 3rd Best Abstracts presented).

7- El-Ghonaimy, E.A., El-Shinawi, M., Khalil, R.A., El-Mamlouk, T., Sloane B., F., Mohamed, M.M. Soluble mediators from tumor associated leukocytes stimulate Akt/PI3k signaling pathway in breast cancer cell lines at the 102nd AACR Annual Meeting 2011, April 2-6, 2011, Orlando, Florida , USA. (Awarded Scholar-in-Training Award).

8- El-Shinawi, M., Tantawy, M., Mostafa, A., Maher, M., Mohamed, M.M., Schneider, R.J. (2011) Human cytomegalovirus infection induces the expression of NF-κB/p65 in the tumor microenvironment of inflammatory breast cancer. AACR’s Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy Special Conference.

9- Mohamed, M.M., El-Shinawi, M., El-Ghonaimy, M., Nouh, M.M., Schneider, R.J., Sloane, B.F. (2011) Infiltrated macrophages and cytokines secreted by tumor draining macrophages potentiate motility of inflammatory breast cancer cells. AACR’s Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy Special Conference.

10- Sabet S.F., Mohamed, M.M., El-Shinawi M., Peng D., Nouh M.A., El-Rifai W. (2011) Hypermethylation and Downregulation of Glutathione Peroxidase-3 in Inflammatory Breast Carcinogenesis. CTRC-AACR San Antonio Breast Cancer Symposium

11- Hosny, M.H., Sabet, S.F., El-Shinawi, M., Mohamed, M.M. (2011) Sequencing analysis of trans-membrane domain of Caveolin-1 gene and expression profile of Caveolin-1 associated proteases in breast cancer patients. Presented in Breast–Gynecological International Cancer Conference (BGICC). 13-14 January, Cairo, Egypt

12- Mohamed M.M. (2010) Contribution of Tumor Microenvironment in Inflammatory Breast Cancer Progression. World Cancer Congress 2010 Tri-Breast Cancer Conference, April 25-27, 2010, Shanghai, China.

13- Mohamed, M.M., El-Shinawi, M., Nouh, A.M., Sloane, B.F. (2010) Macrophage infiltration and cathepsin B expression in the tumor microenvironment of inflammatory breast cancer patients correlates with lymph node metastasis Presented in Joint MRS-AACR Conference: Metastasis and the Tumor Microenvironment, Philadelphia, USA.

14- El-Shinawi, M., Abdelwahab S.F., Sobhy M., Nouh M. A., Mohamed M.M. and Sloane B.F.(2009) Capturing Cells Migrating from Breast Tumor Microenvironment: Innovative Surgical Approach Abstract presenteded in the 100th Annual meeting of the American Association for cancer research APRIL 18 – 22, 2009 Colorado convention center Denver, CO, USA.

15- Mohamed M.M., Dosescu, .J, Cavallo-Medved, D., Rudy, D., Sameni, M., Moin, K., Sloane B.F. (2008) Changes in protease expression and cytokine profiles of human monocytes in response to breast tumor cells. Advances in Cancer Research: From the Laboratory to the Clinic, Dead Sea, Jordan.

16- Mohamed, M.M., Cavallo-Medved, D., Dosescu, .J, Rudy, D., Sameni, M., Moin, K., Sloane, F.B. (2007) Interactions between human monocytic cells and human inflammatory breast cancer cells modulate expression of E-cadherin, caveolin-1 and a caveolae-associated protease, cathepsin B.         98th Annual meeting of the American Association for cancer research Los Angeles, CA, USA, 14th-18th April 2007

17- (2006). Active monocytes/macrophages enhance growth and invasion of breast carcinoma cells in vitro. 97th Annual meeting of the American Association for Cancer Research. Washington, D.C.

18- Mohamed M.M., Dosescu, J., Cavallo-Medved, D., Rudy, D., Sameni, M., Moin, K., Sloane B.F. (2006) Secretions of Breast Tumor Cells Activate the Proteolytic Pathways of Human Monocytes. P. 21 BioVision Alexandria 26-29 April 2006, Alexandria, Egypt.

19- Mohamed, M.M., Dosescu, J., Olive, M., Moin, K. and Sloane, B.F. (2006). The potential role of macrophages in breast cancer progression implies protease activation Association of Egyptian American Scholars 34th Annual International Conference

20- Mohamed M.M., Dosescu, .J, Cavallo-Medved, D., Rudy, D., Sameni, M., Moin, K., Sloane B.F. (2005) Secretions of Breast Tumor Cells Activate the Proteolytic Pathways of Human Monocytes. B16   AACR Special Conference in Cancer Research Cancer, Proteases, and the Tumor Microenvironment Hyatt Regency Coconut Point Resort and Spa Bonita Springs, Florida

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